ExoFauna/Duo is a two-player card game that features one part area control, one part tile-laying, and one part combo building. Each player has a deck of 24 organisms (three copies each of eight unique organisms), and each organism has its own instinct status (scavenger, predator, or swarming) and an adaptation power unique to it. Two watering holes start in play. During a player's turn, they play two organisms from their hand next to either watering hole, each of which can have eight organism cards around it. When an organism is played next to a watering hole, its instinct is always used, granting the player a special ability. Then, if the played organism is the only organism of that name at that watering hole, the player may use its adaptation power, which can trigger a number of combos and additional effects. After playing an organism and carrying out its effects, any watering hole surrounded by eight organisms is resolved and awarded to one of the players. The first player to claim two watering holes wins.

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