The game is played like the basic "Rummy" or "500" card games. Drawing from the hand they are dealt, the deck and/or the discard pile, players try to obtain the proper cards to build as many nucleotides and complementary base pairs as possible. Each deck includes 94 cards - 10 cytosine, 10 adenine, 10 guanine, 10 thymine, 10 hydrogen bonding, 20 phosphate, 20 sugar, and 4 wild.

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