Zombie ApocalyOOPS takes place in a not-so-distant future, where scientists who have been researching immortality have accidentally created zombies instead. Fortunately, the condition can be reversed, though there may be some residual side-effects. In the meantime though... players must battle each other to survive! Zombie ApocalyOOPS is a fast paced card game in which players switch between human and zombie in a free-for-all battle. Each card is split in half and color coded. Blue halves are playable by humans, green by zombies, and white by any race. If a player chooses (or is forced) to change race, they must flip their hand to the corresponding color. The game also includes 22 Event cards, of which a random 10 are used each game. This provides high replay value, and also a chaotic element similar to what one might expect in a real zombie apocalypse.

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