Chem Cubes comes with rules for 8 different sub-games that are "designed to teach and reinforce the basic skills regarding elements and the periodic table." The games are arranged in order of the skills that are to be mastered, so the first game is simpler and easier, and the eighth game is a little more complex and difficult. All games consist of some combination of rolling 6 dice (each having the abbreviation of 6 different periodic table elements on them), and either naming the elements or their chemical properties out loud for points.

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