Pigskin Vegas (endorsed by Jimmy the Greek) allows you to bet on real-time football games. You determine how much you're willing to wager an what will happen on the next play. Everything from the simple (First Down/No First Down & Pass Play/Run Play) to the complex (QB sack before the next first down). The odds are on the board so all you need to do is place your chips and find someone else to cover your bet.

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