Mad Science The Card Game is a family friendly game played in three phases. Players must first construct a creature from bodies and parts. then they battle the Horrible Experiment created by Dr. Emil Knutberger to save the city. Finally, they fight each other, knocking off parts until only one creation remains standing. Phase One is purely cards while Phases Two and Three also make use of a D6. The core set works best with 2 or 3 players. Expansion sets allow for up to 6 players. There is also a Phase Two Solitary version of play.

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